Tadeusz A Wysocki

Use of Communication Theory to Model Molecular Signaling

In order to study biological processes that happen at cellular level, like cell metabolism, viral infections or those processes that involve human interactions with living cells, like cell transfection or targeted drug delivery, accurate, scalable and inexpensive models are necessary. The talk will present an application of standard communication theory techniques to develop such simulation models that can significantly speedup analysis of those processes and reduce expenses associated with laboratory experiments. It can also help in identifying bottlenecks in signaling pathways and facilitate studying cell responses to changes in underlying conditions (e.g. initial concentrations of proteins, changing reaction speeds, etc.). The proposed solution is to use a modeling approach based on queuing theory and stochastic modeling to build simulation models tailored to particular biological/medical application. In the presentation, the fundamental aspects of the modelling as well as some of the developed models will be presented and results of simulations compared with the available experimental data.

Tadeusz Antoni Wysocki (IEEE M'94 - SM'98), received the M.Sc.Eng. degree with the highest distinction in telecommunications from the Academy of Technology and Agriculture, Bydgoszcz, Poland, in 1981. In 1984, he received his Ph.D. degree, and in 1990, was awarded a D.Sc. degree (habilitation) in telecommunications from the Warsaw University of Technology. In 1992, he moved to Perth, Western Australia to work at Edith Cowan University. He spent the whole 1993 at the University of Hagen, Germany, within the framework of Alexander von Humboldt Research Fellowship. In December 1998, he moved to the University of Wollongong, NSW, as an Associate Professor, within the School of Electrical, Computer and Telecommunications Engineering. Since the fall of 2007, he has been with the University of Nebraska - Lincoln as a Professor of Electrical and Computer. He also holds a title of a Professor at the UTP University of Science and Technology, Bydgoszcz, Poland. The main areas of his research interests include: space-time signal processing, diversity combining, indoor propagation of microwaves, molecular communications at nano-scale and its applications in microbiology and medicine. He is an author or co-author of over 260 research papers.